Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided
申请公布号
EP2182063(A2)
申请公布日期
2010.05.05
申请号
EP20090150172
申请日期
2004.09.17
申请人
ISIS PHARMACEUTICALS, INC.
发明人
FREIER, SUSAN M.;DOBIE, KENNETH W.;MARCUSSON, ERIC G.;SWAYZE, ERIC E.;BHAT, BALKRISHEN;GRAFF, JEREMY R.;KONICEK, BRUCE W.
