| 摘要 |
A liquid chromatography diverter for reducing or eliminating matrix interfering components in a biopharmaceutical product in a liquid chromatography-mass spectrometry system, comprising: an eluant input port of a six-port injection valve, the eluant input port being in a liquid flow connection with a liquid chromatography column; and a mass spectrometer output port of the six-port injection valve, the mass spectrometer output port being in a liquid flow connection with a mass spectrometer; wherein the six-port injection valve is configured to be automatically switched between a waste flow configuration and a source flow configuration, the waste flow configuration diverting an entire flow from the eluant input port to be directed to waste, and the source flow configuration directing the entire flow from the eluant input port to be directed to the mass spectrometer;the diverter further comprising a calibrant flow loop between two adjacent ports of the six-port injection valve, the waste flow configuration directing flow of a calibrant liquid through the calibrant flow loop and to the mass spectrometer, and the source flow configuration directing flow of the calibrant liquid to waste and forming a closed flow loop that includes the calibrant flow loop. |
