发明名称 |
Phenyl-1,2,4-oxadiazolone derivatives, processes for their preparation and methods for their use as pharmaceuticals |
摘要 |
The inventive compounds of the present invention are comprised of phenyl and pyridinyl-1,2,4-oxadiazolone derivatives and their physiologically acceptable salts and functional derivatives that are shown to provide peroxisome proliferator activator receptor (PPARdelta) agonist activity. The compounds of the present invention are comprised of the formula: wherein the substituents R1-R5 and R7-R10 are defined herein. The compounds are therapeutically effective in the regulation and modulation of lipid and carbohydrate metabolism in mammals and are thus suitable for the treatment of diseases such as type-2 diabetes, atherosclerosis, cardiovascular disorders and the like.
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申请公布号 |
US7709481(B2) |
申请公布日期 |
2010.05.04 |
申请号 |
US20080055780 |
申请日期 |
2008.03.26 |
申请人 |
SANOFI-AVENTIS |
发明人 |
KEIL STEFANIE;URMANN MATTHIAS;BERNARDELLI PATRICK;GLIEN MAIKE;WENDLER WOLFGANG;CHANDROSS KAREN;LEE LAN |
分类号 |
A61K31/5377;A61K31/4245;A61P3/00;C07D413/12;C07D413/14 |
主分类号 |
A61K31/5377 |
代理机构 |
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代理人 |
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地址 |
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