HUMANIZED ANTIBODY WITH NUCLEIC NUCLEIC ACID-HYDROLYZING ACTIVITY AND TUMOR CELL-PENETRATING ABILITY AND USES THEREOF

摘要

PURPOSE: A humanized antibody having nucleic acid hydrolysis ability and cancer cell infiltration ability is provided to specifically bind to and hydrolyze a nucleic acid and to ensure low immune reaction in a human body. CONSTITUTION: An immunoglobulin or single side chain antibody(scFv) fragment contains epitope of heavy chain variable region or light chain variable region. The immunoglobulin is immunoglobulin G, humanized 3D8 antibody. The heavy chain variable region is a protein comprising a sequence of sequence number 15. The VL is a protein comprising a sequence of sequence number 16. A composition for preventing or treating cancer contains the immunoglobulin or single side chain antibody(scFv) fragment as an active ingredient.