发明名称 |
Interacting polypeptide comprising a heptapeptide pattern and a cellular penetration domain |
摘要 |
The invention relates to an interacting polypeptide consisting of or comprising a heptapeptide pattern of sequence X1X2X3X4X5X6X7 and a transduction domain, characterized in that it is a chimera polypeptide, the amino acid X7 is located between 5 and 35 amino acids of the C-terminal end of said polypeptide, and that the domain (b) is situated in C-terminal relative to pattern (a). The invention also relates to screening methods for identifying interacting polypeptides capable of modifying the phenotype of a cell and to uses of interacting polypeptides as mentioned in phenotypic screens or for therapeutic purposes. Lastly, the invention concerns interacting polypeptides capable of modifying the function of the HIV-1 Rev viral protein.
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申请公布号 |
US7709606(B2) |
申请公布日期 |
2010.05.04 |
申请号 |
US20060396196 |
申请日期 |
2006.03.30 |
申请人 |
ECOLE NORMALE SUPERIEURE DE LYON;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE |
发明人 |
JALINOT PIERRE;ROISON ARMELLE;ROBIN JEAN-PHILIPPE |
分类号 |
C07K14/00;C07K19/00;C12Q1/00;G01N33/569;G01N33/68 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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