Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor Xla inhibitors

摘要

Disclosed is a compound of Formula (I), or a stereoisomer, tautomer, pharmaceutically acceptable salt, or solvate thereof, wherein A is a carbocycle or heterocycle as described, M is a heterocycle chosen from the pictured options, and wherein the other substituents are as described in the specification. Also disclosed are processes for the preparation of such compounds. Also disclosed is the use of the compound for treating a thromboembolic disorder.