INTERMEDIATE AND PROCESS FOR PREPARING OF ß-ANOMER ENRICHED 2 1 -DEOXY, 2 1, 2 1-DIFLUORO-D-RIBOFURANOSYL NUCLEOSIDES

摘要

A HIGHLY STEREOS ELECTIVE, SIMPLE AND ECONOMICAL GLYCOSYLATION PROCESS FOR PREPARATION OF -ANOMER ENRICHED 21-DEOXY-21,21-D-RIBOFURANOSYL DIFLUORONUCLEOSIDES OF FORMULA (II), AND PHYSIOLOGICALLY ACCEPTABLE SLATS THEREOF, IN PARTICULAR, THE - ENRICHED ANOMER OF GEMCITABINE HYDROCHLORIDE OF FORMULA (IIB) IN PURITY OF >99% IS PROVIDED THROUGH UTILIZATION OF A NOVEL TRICHLOROACETIMIDATE OF FORMULA (I).