| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for screening presence of a malignant condition using an antibody specific for mesothelin/MPF and/or mesothelin/MPF related antigen so as to detect polypeptides naturally present in a soluble form. SOLUTION: The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble forms of mesothelin polypeptides, including mesothelin related antigen (MRA). In particular the invention provides a nucleic acid sequence encoding MRA and an MRA variant. The invention also provides a method of screening for the presence of a malignant condition in a subject by detecting reactivity of an antibody specific for a mesothelin polypeptide with a molecule naturally occurring in soluble form in a sample from such a subject, and by hybridization screening using an MRA nucleotide sequence, as well as other related advantages. COPYRIGHT: (C)2010,JPO&INPIT
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