Compounds containing a 1,2,3-triazolo[4,5-d]pyrimidine-7-yl radical linked to fused ring moieties for the inhibition of NAD(P)H oxidases and platelet activation

摘要

Disclosed are compounds of the general Formula (I) which are useful for the inhibition of NAD(P)H oxidases (NOX) and / or for the inhibition of platelet activation, where het is a five or six-membered N-heteroaryl or a fused five or six-membered N-heteroaryl; X is S; AB is the 1,2,3-triazolo[4,5-d]pyrimidine-7-yl radical as represented by the general Formula (II); where the remaining substituents are as defined herein. Of particular importance is the compound 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine. .