| 摘要 |
<p>The invention relates to a process for obtaining 7alpha-methyl steroids with the formula I (space for formula) where R1 is hydrogen, methyl or -C=CH, R2 is (CH2)nOH, where n is 0, 1 or 2; which consists in the 1,6-conjugated addition of a Grignard reagent CH3MgX mediated by copper, X being a halogen atom, at a 4,6-non-saturated 3-ketosteroid with the formula II (space for formula) where R1 and R2 were previously defined, they comprising the protection of a hydroxy group of the steroid with the formula II, with a trialkyl silyl, where the alkyl group is defined as an alkyl group which has 1 to 4 carbon atoms, followed by treating the steroid with the formula II with the hydroxy group protected, with the Grignard reagent, as well as to a compound used as intermediary in obtaining 7alpha-methyl steroids, 21-hydroxy-19-horpregn-4,6-diene-3-one. The compounds obtained by this process, according to the invention, are used in the hormonal therapy.</p> |
