发明名称 |
SELENOCYSTEINE MEDIATED HYBRID ANTIBODY MOLECULES |
摘要 |
The invention provides methods and compositions employing hybrid molecules of a synthetic molecule and antibody or antibody fragment comprising a selenocysteine residue, wherein the synthetic molecule is covalently linked to the antibody or antibody fragment at the selenocysteine residue. The invention also provides a composition comprising a hybrid molecule as described above and a pharmaceutically acceptable carrier. The invention further provides for methods of making the hybrid molecules, and methods of using the hybrid molecule described above to inhibit cell surface receptor binding. |
申请公布号 |
US2010104510(A1) |
申请公布日期 |
2010.04.29 |
申请号 |
US20090570796 |
申请日期 |
2009.09.30 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN;SERVICES |
发明人 |
RADER CHRISTOPH;HOFER THOMAS;BURKE, JR. TERRENCE;THOMAS JOSHUA |
分类号 |
A61K51/00;A61K39/395;A61P25/00;A61P35/04;C12N5/02;C12N5/071;C12P21/06 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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