CHEMOATTRACTANTS INHIBITORS

摘要

The authors of the present invention have found that, surprisingly, ob/ob mice present a dramatic decrease in the resident mesenchymal stem cell pool of several organs, including skeletal muscle, heart, adipose tissue and lung. Moreover, the results herein presented show that this decrease is due to the migration of said MSC cells to the adipose tissue. Evidence is also provided that said migration process is largely explained by the production of high levels of inflammatory cytokines within the adipose tissue.