发明名称 |
PYRIMIDINYL PYRIDONE INHIBITORS OF JNK |
摘要 |
This application discloses novel pyrimidinyl pyridone derivatives according to Formulae I and II, wherein R1 and R2 are defined as described herein, which inhibit JNK. The compounds disclosed herein are useful to modulate the activity of JNK and treat diseases associated with excessive JNK activity. The compounds are useful to treat autoimmune, inflammatory, metabolic, and neurological diseases as well as cancer. Also disclosed are compositions comprising the compound of Formula I and methods of treatment comprising administering a therapeutically effective amount of the compound of Formula I to a subject in need thereof. |
申请公布号 |
WO2010046273(A2) |
申请公布日期 |
2010.04.29 |
申请号 |
WO2009EP63327 |
申请日期 |
2009.10.13 |
申请人 |
F. HOFFMANN-LA ROCHE AG;BOICE, GENEVIEVE N.;GONG, LEYI;MCCALEB, KRISTEN LYNN;PALMER, WYLIE SOLANG |
发明人 |
BOICE, GENEVIEVE N.;GONG, LEYI;MCCALEB, KRISTEN LYNN;PALMER, WYLIE SOLANG |
分类号 |
C07D487/04;A61K31/519;A61P29/00 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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