Apparatuses and methods for accessing and disrupting a tissue are disclosed herein. In one embodiment, a method includes inserting a distal end portion of a medical device into a biological body such that a cutting member disposed at a distal end of the medical device is at a first location within the biological body. A tissue is disrupted at the first location within the biological body. The distal end portion of the medical device is reconfigured from a first configuration in which the distal end portion of the medical device has a first curvature to a second configuration in which the distal end portion of the medical device has a second curvature different than the first curvature and the cutting member is at a second location within the biological body. A tissue is then disrupted at the second location within the biological body.
