The present invention relates to the elucidation of specific molecular features of endogenous 2-oxoacid molecules and their derivatives for activating hypoxia-inducible e gene expression by inactivating hypoxia-inducible factor hydroxylating enzymes. This invention identifies agents that can be used to induce tissue vascularization, treat anemias, induce tolerance to stroke and heart attacks, improve tissue healing and improve organ transplantation.
申请公布号
WO2005094236(A9)
申请公布日期
2010.04.29
申请号
WO2004US37045
申请日期
2004.11.08
申请人
HENRY M. JACKSON FOUNDATION;VERMA, AJAY;LU, HUASHENG;FORBES, ROBERT;DALGARD, CLIFTON;MOHYELDIN, AHMED;ZENK, RONALD
发明人
VERMA, AJAY;LU, HUASHENG;FORBES, ROBERT;DALGARD, CLIFTON;MOHYELDIN, AHMED;ZENK, RONALD