发明名称 |
HIGH-THROUGHPUT ASSAY FOR EVALUATING DIPEPTIDYL PEPTIDASE I ACTIVITY |
摘要 |
<p>A method of screening a compound which modulates dipeptidyl peptidase I (DPPI) activities comprises the steps of adding a peptide substrate of DPPI to a reaction mixture which comprises DPPI and a compound, wherein the peptide substrate of DPPI has at least 3 amino acids and binds to a binding site of DPPI in addition to the S1-S2 site; and measuring the molecular weight of the substrate, wherein a change in the molecular weight of the substrate is indicative of the presence of DPPI activity.</p> |
申请公布号 |
WO2010048306(A1) |
申请公布日期 |
2010.04.29 |
申请号 |
WO2009US61509 |
申请日期 |
2009.10.21 |
申请人 |
JOHNSON & JOHNSON PHARMACEUTICAL RESEARCH & DEVELOPMENT, L.L.C.;OLSON, MATTHEW;TODD, MATTHEW |
发明人 |
OLSON, MATTHEW;TODD, MATTHEW |
分类号 |
C12Q1/37;C07K7/06;C07K7/08;C07K14/81 |
主分类号 |
C12Q1/37 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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