SILICON DIOXIDE NANOPARTICLES AND THEIR USE FOR VACCINATION
摘要
The invention relates to ultra-small, monodisperse nanoparticles of silicon dioxide with at least one antigen attached to their surface. The nanoparticles can be used for the immunoprophylaxis or immunotherapy of cancer. The invention also provides a method of targeting antigens at antigen-presenting cells and of activating the immune system, the efficiency of targeting and/or immune activation being adjusted via the particle characteristics. The invention also relates to methods of active and passive immunization of a mammal.
申请公布号
WO2010006753(A3)
申请公布日期
2010.04.29
申请号
WO2009EP05078
申请日期
2009.07.13
申请人
MERCK PATENT GMBH;WEIGANDT, MARKUS;HANEFELD, ANDREA;KUEBELBECK, ARMIN;LARBIG, GREGOR
发明人
WEIGANDT, MARKUS;HANEFELD, ANDREA;KUEBELBECK, ARMIN;LARBIG, GREGOR