MODIFIED PROLYL ENDOPEPTIDASES FOR THE TREATMENT OF DISEASES CAUSED BY IMMUNE RESPONSES TO DIETARY PROTEINS

摘要

Provided are prolyl endopeptidases that have been produced by alteration of the amino acid sequence of a naturally occurring prolyl endopeptidase, thereby enhancing the proteolysis by said prolyl endopeptidase of one or more peptides produced by the digestion of gluten. Further provided are prolyl endopeptidase in which enhanced proteolysis results from the improved activity of the modified prolyl endopeptidase under conditions inside the human alimentary canal, or from increased resistance of the modified prolyl endopeptidase to digestion by one or more digestive enzymes in the human alimentary canal.