发明名称 |
VACCINE COMPOSITION CONTAINING SYNTHETIC ADJUVANT |
摘要 |
Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier. |
申请公布号 |
WO2009143457(A3) |
申请公布日期 |
2010.04.29 |
申请号 |
WO2009US45033 |
申请日期 |
2009.05.22 |
申请人 |
INFECTIOUS DISEASE RESEARCH INSTITUTE;REED, STEVEN, G.;CARTER, DARRICK |
发明人 |
REED, STEVEN, G.;CARTER, DARRICK |
分类号 |
A61K31/7028;A61K39/008;A61K39/04;A61K39/145;A61P37/00 |
主分类号 |
A61K31/7028 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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