PHENANTHROINDOLIZIDINE COMPOUND AND NFKB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT

摘要

A novel compound having an excellent NF?B inhibitory effect.  Specifically disclosed is a compound represented by formula (1) or a salt thereof. (In the formula, R1 represents a hydrogen atom, a lower alkyl group, a lower alkyloxy group or a halogen atom; R2 represents a hydroxy group or a lower alkyloxy group; R3 represents a hydrogen atom, a lower alkyl group or a halogen atom; R4 represents a hydrogen atom or a lower alkyloxy group; R5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom or a hydroxy group, or alternatively forms a methylenedioxy group or an isopropylidenedioxy group together with R6; R6 represents a hydrogen atom or a lower alkyloxy group, or alternatively forms a methylenedioxy group or an isopropylidenedioxy group together with R5; R7 represents a hydrogen atom or a lower alkyl group; and R8 represents a hydrogen atom, a hydroxy group, an amino group or a lower alkylcarbonyloxy group (excluding the case wherein R1, R3, R4 and R7 are hydrogen atoms, R2 and R8 are hydroxy groups, and R5 and R6 are methoxy groups).)