发明名称 |
ADJUVANT COMPOSITION COMPRISING ALUMINIUM PHOSPHATE AND 3D-MPL |
摘要 |
<p>An immunogenic composition comprising: (i) an antigen; (ii) an aluminum phosphate adjuvant; and (iii) a 3-0-deacylated monophosphoryl lipid A adjuvant. Components (ii) and (iii) can also be used as a separate adjuvant system. Various features of the compositions are disclosed, including that at least 50[err] of the 3-0-deacylated monophosphoryl lipid A adjuvant should be adsorbed to the aluminum phosphate adjuvant. The adjuvant mixture is particularly useful with hepatitis B virus surface antigen.</p> |
申请公布号 |
SG160328(A1) |
申请公布日期 |
2010.04.29 |
申请号 |
SG20100010262 |
申请日期 |
2006.02.16 |
申请人 |
NOVARTIS VACCINES AND DIAGNOSTICS, INC. |
发明人 |
OAEHAGAN, DEREK |
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