发明名称 |
METHOD FOR THE PRODUCTION OF ANTIBODIES |
摘要 |
The current invention is related to a method for the production of a human monoclonal antibody from a immunodeficient non-human animal, said method comprising contacting a new borne immunodeficient non-human animal with a human fetal liver stem cell (FL cell) to generate an immune transplanted non-human animal (reconstituted animal), subsequently contacting said reconstituted animal with a antigen, collecting from said reconstituted animal a human cell producing human antibody against said antigen, and isolating said antibody from said antibody producing cell.
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申请公布号 |
US2010105073(A1) |
申请公布日期 |
2010.04.29 |
申请号 |
US20090603642 |
申请日期 |
2009.10.22 |
申请人 |
LIFKE ALEXANDER;LIFKE VALERIA;MUELLER-BECKMANN BERND;SCHNITZER TOBIAS |
发明人 |
LIFKE ALEXANDER;LIFKE VALERIA;MUELLER-BECKMANN BERND;SCHNITZER TOBIAS |
分类号 |
G01N33/53;C12N5/0781;C12P21/08 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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