FORMULATIONS CONTAINING LARGE-SIZE CARRIER PARTICLES FOR DRY POWDER INHALATION AEROSOLS

摘要

A dry powder inhaler may include a drug chamber configured to contain a formulation including carrier particles and working agent particles, a mouthpiece configured to direct flow of working agent particles to a user, and a retaining member proximal the mouthpiece. The retaining member be sized and arranged to prevent flow of substantially all carrier particles to the user while permitting flow of working agent particles to a user. The inhaler may include a formulation including carrier particles for delivering working agent to the pulmonary system of a patient. The carrier particles may have an average sieve diameter greater than about 500 µm. The carrier particles may be one of polystyrene, PTFE, silicone glass, and silica gel or glass.