发明名称 |
PROTEASES TARGETING AGENTS |
摘要 |
<p>A protein inhibitor from Sulfolobulus Solfataricus and peptides thereof, which both have the ability to inhibit AARE and elastase are described. Similarly to the eukaryotic counterparts, the recombinant protein is able to inhibit in vitro the bovine alf a-chymotrypsin with a high specificity, and the porcine elastase but not all commercial available trypsins, features which distinguish all the members belonging to the family PEBP. Through site-specific mutagenesis techniques of the gene codifying SsCEI, it has been recognized the "reactive site loop" - RCL - on the inhibitor, responsible for the interaction with the eukarial protease target already identified. The inhibitor and the peptides thereof can be used as new compounds capable of modulating cognitive enhancement cardiovascular diseases, cancer, inflammation, hematological diseases, neurological diseases and urological diseases.</p> |
申请公布号 |
WO2010046944(A1) |
申请公布日期 |
2010.04.29 |
申请号 |
WO2009IT00478 |
申请日期 |
2009.10.23 |
申请人 |
CONSIGLIO NAZIONALE DELLE RICERCHE;ROSSI, MOSE;PALMIERI, GIANNA;CATARA, GIULIANA;MENOTTI, RUVO |
发明人 |
ROSSI, MOSE;PALMIERI, GIANNA;CATARA, GIULIANA;MENOTTI, RUVO |
分类号 |
C07K14/81 |
主分类号 |
C07K14/81 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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