Biphenyl derivatives and their use in treating hepatitis C

摘要

A compound which is a biphenyl derivative of formula (I), or a pharmaceutically acceptable salt thereof wherein: R1 is a C1-C6 alkyl group or a moiety -A1, -L1-A1, -A1-A1', -L1-A1-A1', -A1-L1-A1', -A1-Y1-A1', -A1-Het1-A1', -L1-A1-Y1-A1', -L1-A1-Het1-A1', -L1-Het1-A1, -L1-Y1-A1, -L1-Y1-Het1-A1, -L1-Het1-Y1-A1, -L1-Y1-Het1-L1', -A1-Y1-Het1-A1', -A1-Het1-Y1-A1', -A1-Het1-L1-A1', -A1-L1-Het1-A1' or -L1-Het1-L1'; - A and B are the same or different and each represent a direct bond or a -CO- NR'-, -NR'-CO-, -NR'-CO2-, -CO-, -NR'-CO-NR''-, -NR'-S(O)2-, -S(O)2-NR'-, -SO2-, -NR'-, -NR'-CO-CO-, -CO-O-, -O-CO-, -(C1-C2 alkylene)-NR'- or -(C1-C2 hydroxyalkylene)-NR' - moiety, wherein R' and R'' are the same or different and each represent hydrogen or C1-C4 alkyl; - R2 and R3 are the same or different and each represent C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy or halogen; n and m are the same or different and each represent 0 or 1 ; R4 is a C1-C6 alkyl group or a moiety -A4, -L4-A4, -A4-A4', -L4-A4-A4' , -A4-L4-A4', -A4-Y4-A4', -A4-Het4-A4', -L4-A4-Y4-A4', -L4-A4-Het4-A4', -L4-Het4-A4, -L4-Y4-A4, -L4-Y4-Het4-A4, -L4-Het4-Y4-A4, -L4-Y4-Het4-L4', -A4-Y4-Het4-A4', -A4-Het4-Y4-A4', -A4-Het4-L4-A4', -A4-L4-Het4-A4' or -L4-Het4-L4', each A1, A4, A1' and A4' are the same or different and represent a phenyl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl or C3-C8 carbocyclyl moiety; each L1 and L4 is the same or different and represents a C1-C4 alkylene or a C1-C4 hydroxyalkylene group; each Y1 and Y4 is the same or different and represents -CO-, -SO- or -S(O)2-; each L1' and L4' is the same or different and represents hydrogen or a C1-C4 alkyl group; and each Het1 and Het4 is the same or different and represents -O-, -S- or -NR'-.