发明名称 |
RNA SEQUENCE MOTIFS IN THE CONTEXT OF DEFINED INTERNUCLEOTIDE LINKAGES INDUCING SPECIFIC IMMUNE MODULATORY PROFILES |
摘要 |
Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α. |
申请公布号 |
EP2179039(A2) |
申请公布日期 |
2010.04.28 |
申请号 |
EP20080789054 |
申请日期 |
2008.08.08 |
申请人 |
COLEY PHARMACEUTICAL GMBH |
发明人 |
JURK, MARION;VOLLMER, JORG, HEINZ |
分类号 |
A61K31/7105;A61K39/39;A61P11/06;A61P37/04;C12N15/117 |
主分类号 |
A61K31/7105 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|