发明名称 |
Arf and Hdm2 interaction domains and the methods of use thereof |
摘要 |
The present invention discloses that the binding of Arf with Dm2, important components of the p53 tumor suppressor pathway, results in specific domains of both proteins undergoing a dramatic transition from dynamically disordered conformations to amyloid-like structures comprised of anti-parallel &bgr;-strands. The invention exploits this discovery by providing unique methods for identifying and/or designing compounds that mimic, inhibit and/or enhance the effect of Arf on Dm2. The present invention also provides specific peptides derived from the binding domains of Arf and Dm2 which co-assemble into supramolecular structures comprised of binary anti-parallel &bgr;-strands. The disclosed peptides may represent structural prototypes for a broader class of peptides that is capable of assembly into supramolecular structures.
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申请公布号 |
US7704703(B2) |
申请公布日期 |
2010.04.27 |
申请号 |
US20040489802 |
申请日期 |
2004.07.23 |
申请人 |
ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. |
发明人 |
KRIWACKI RICHARD;BOTHNER BRIAN;LEWIS WILLIAM |
分类号 |
G01N33/53;C07K5/11;C07K14/47;G01N33/574;G06F19/00 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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