| 发明名称 |
Camptothecins conjugated in position 7 to cyclic peptides as cytostatic agents |
| 摘要 |
Compounds of Formula (I) are described in which the R1 group is as defined in the specification and includes the condensation of the camptothecin molecule in position 7 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors αv&bgr;3 and αv&bgr;5 and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.
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| 申请公布号 |
US7705012(B2) |
申请公布日期 |
2010.04.27 |
| 申请号 |
US20050596015 |
申请日期 |
2005.05.04 |
| 申请人 |
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.;INSTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI |
发明人 |
PISANO CLAUDIO;GIANNINI GIUSEPPE;TINTI MARIA ORNELLA;VESCI LOREDANA;ALLOATTI DOMENICO;PENCO SERGIO;DAL POZZO ALMA;MINGHONG NI;DALLAVALLE SABRINA;MERLINI LUCIO;ZUNINO FRANCO |
| 分类号 |
A61K31/4745;A61K38/00;A61K38/08;C07D491/22;C07K7/52;C07K7/64 |
主分类号 |
A61K31/4745 |
| 代理机构 |
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