发明名称 |
IMPROVEMENTS IN MS/MS SCAN METHODS FOR A QUADRUPOLE/TIME OF FLIGHT TANDEM MASS SPECTROMETER |
摘要 |
There is provided a method of effecting mass analysis on an ion stream, the method comprising passing the ion stream through a first mass resolving spectrometer, to select parent ions having a first desired mass-to--charge ratio. The parent ions are then subject to collision-induced dissociation (CID) to generate product ions, and the product ions and any remaining parent ions are trapped; the CID and trapping can be carried out together in a linear ion trap. Periodically pulses of the trapped ions are released into a time of flight (TOF) instrument to determine the mass-to-charge ratio of the ions. The delay between the release of the pulses and the initiation of the push-pull pulses of the TOF instrument are adjusted to maximize the duty cycle efficiency and hence the sensitivity for a selected ions with a desired mass-to-charge ratio. This technique can be used to optimize the performance for a parent ion scan, and MRM scan or a neutral loss scan.
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申请公布号 |
CA2349416(C) |
申请公布日期 |
2010.04.27 |
申请号 |
CA20012349416 |
申请日期 |
2001.06.01 |
申请人 |
MDS INC., DOING BUSINESS AS MDS SCIEX |
发明人 |
CHERNUSHEVICH, IGOR;THOMSON, BRUCE |
分类号 |
H01J49/34;H01J49/40;H01J49/42 |
主分类号 |
H01J49/34 |
代理机构 |
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