发明名称 |
NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF. |
摘要 |
<p>The invention relates to a compound of the formula (I) in which: A is an NR1R'1 or (C1-C6)alcoxy group; Z et Z' are respectively N and CH; N and CF; N and N; CH and CH; CH and N; L is a -CH=CH- or -CH2CH2- or -(CH2)n-Y- group; R1 and R2 are such that: (i) R1 is: a hydrogen atom; an aryl group optionally substituted with one or more halogen atoms; a heteroaryl group; a (C3-C6)cycloalkyl group; a (C1-C6)alkyl group and R'1 is a hydrogen atom or a (C1-C6)alkyl group; or (ii) R1 and R'1 form together with the nitrogen atom to which they are bonded a heterocycloalkyl group; R2 is a -Q-R4 group; Q is an oxygen atom or the -NH- group; R4 is: a hydrogen atom; a heteroaryl group; a (C3-C6)cycloalkyl group; an optionally substituted (C1-C6)alkyl group; R3 is at least one substituent of the pyridine nucleus.</p> |
申请公布号 |
MX2010003445(A) |
申请公布日期 |
2010.04.27 |
申请号 |
MX20100003445 |
申请日期 |
2008.09.26 |
申请人 |
SANOFI-AVENTIS |
发明人 |
PIERRE CASELLAS;SAMIR JEGHAM;PIERRE FRAISSE;MONSIF BOUABOULA;JEROME ARIGON;CLAUDE BERNHART;ROMAIN COMBET;SANDRINE HILAIRET |
分类号 |
C07D213/82;A61K31/4406;A61P35/00;C07D211/38;C07D211/42;C07D211/46;C07D213/30;C07D213/36;C07D213/73;C07D213/74;C07D213/80;C07D239/42;C07D307/14;C07D401/12;C07D401/14;C07D405/12;C07D405/14 |
主分类号 |
C07D213/82 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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