发明名称 |
Regulation of food intake by modulation of long-chain fatty acyl-CoA levels in the hypothalamus |
摘要 |
Methods of reducing food intake and glucose production in a mammal, or restoring hepatic autoregulation are provided. The methods involve increasing long-chain fatty acyl-Co-A (LC-CoA) levels in the hypothalamus, or stimulating efferent fibers in the hepatic branch of the vagus nerve. Also provided are methods of increasing food intake and glucose production in a mammal. The methods involve decreasing long-chain fatty acyl-Co-A (LC-CoA) levels in the hypothalamus of the mammal.
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申请公布号 |
US7705016(B2) |
申请公布日期 |
2010.04.27 |
申请号 |
US20040545056 |
申请日期 |
2004.02.12 |
申请人 |
ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY |
发明人 |
ROSSETTI LUCIANO;OBICI SILVANA |
分类号 |
A61K31/44;A61K;A61K6/00;A61K31/00;A61K31/17;A61K31/20;A61K31/27;A61K31/41;A61K31/7088;A61K31/7105;A61K38/43;A61K38/44;A61K38/45;A61K38/46;A61K39/395;A61K48/00;A61P31/12;A61P31/18;A61P35/00;C07K16/18;C12N9/10 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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