| 发明名称 |
Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof forβ-secretase modulation |
| 摘要 |
The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit &bgr;-secretase (BACE) and treat &bgr;-amyloid deposits and neurofibrillary tangles.
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| 申请公布号 |
US7705030(B2) |
申请公布日期 |
2010.04.27 |
| 申请号 |
US20080180795 |
申请日期 |
2008.07.28 |
| 申请人 |
WYETH LLC |
发明人 |
MALAMAS MICHAEL SOTIRIOS;ZHOU PING;FOBARE WILLIAM FLOYD;SOLVIBILE WILLIAM RONALD;GUNAWAN IWAN SUWANDI;ERDEI JAMES JOSEPH;YAN YINFA;ANDRAE PATRICK MICHAEL;QUAGLIATO DOMINICK ANTHONY |
| 分类号 |
A61K31/4178;A61K31/4439;A61K31/506;C07D233/88;C07D401/14;C07D403/14 |
主分类号 |
A61K31/4178 |
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