INTERFERON-.GAMMA. PRODUCTION INDUCING POLYPEPTIDE, MONOCLONAL ANTIBODY, AND AGENT FOR INTERFERON-.GAMMA. SUSCEPTIVE DISEASE

摘要

A polypeptide which has a molecular weight of 18,500~3,000 daltons on SDS-PAGE and a pI of 4.9~1.0 on chromatofocusing. The polypeptide strongly induces the IFN-.gamma. production by immunocompetent cells with only a small amount, and dose not cause serious side effects even when administered to human in a relatively-high dose. It is readily prepared by using a monoclonal antibody obtained from hybridomas, and incorporated into agents for treating and/or preventing malignant tumors, viral diseases, bacterial infectious diseases, and immune diseases.