| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a free base (R)-3-[1-(2,6-dichloro-3-fluoro-phenyl)- ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine in crystalline form, having a powder X-ray diffraction pattern with peaks at diffraction angles (2) 15.70.1, 17.30.1 and 19.70.1. The invention also relates to a pharmaceutical composition, to methods of treating cancer in mammals, as well as to a method of treating abnormal cell growth in mammals in need of such treatment. ^ EFFECT: obtaining an novel biologically active compound having the said inhibitory activity. ^ 12 cl, 1 ex, 3 tbl, 2 dwg |
