METHODS AND COMPOUNDS FOR ANTIMICROBIAL INTERVENTION
摘要
The present invention provides Wall Teichoic Acid biosynthesis inhibitors such as compound 1835F03 (targocil) and related synthetic analogs. The invention also provides pharmaceutical compositions thereof and methods for treating bacterial infection and the suppression of growth of bacterial cells by administering a Wall Teichoic Acid biosynthesis inhibitor. The invention is particularly useful for the treatment of Methicillin-resistant Staphylococcus aureus (MRSA). The invention further provides procedures for the syntheses of Wall Teichoic Acid biosynthesis inhibitors. The invention also provides methods for the identification of antibacterial therapeutic agents.
申请公布号
WO2009151561(A3)
申请公布日期
2010.04.22
申请号
WO2009US03424
申请日期
2009.06.05
申请人
PRESIDENT AND FELLOWS OF HARVARD COLLEGE;WALKER KAHNE, SUZANNE;SWOBODA, JONATHAN, G.;MEREDITH, TIMOTHY, C.;LEE, KYUNGAE