| 摘要 |
PURPOSE: A compound suppressing HIV(human immunodeficiency virus) reverse transcriptase is provided to treat AIDS by targeting HIV RT of wild type and mutant type HIVs. CONSTITUTION: A compound of chemical formula I or its pharmaceutically acceptable tautomer, salt, solvent compound and/or ester have(has) an activity of suppressing HIV reverse transcriptase. A pharmaceutical composition contains therapeutically effective amount of chemical formula I, or its pharmaceutically acceptable salt, solvent compound and/or ester; and pharmaceutically acceptable carrier or excipient. The pharmaceutical composition additionally contains one or more active drug(has). The active drug is HIV protease inhibitor, HIV non-nucleoside transcriptase inhibitor, HIV nucleoside transcriptase inhibitor, HIV nucleotide reverse transcriptase inhibitor, HIV integrase inhibitor, gp41 inhibitor, CXCR4 inhibitor, gp120 inhibitor, CCR5 inhibitor, CCR8 inhibitor, entry inhibitor, or RNase H inhibitor.
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