发明名称 |
VIRUS-EXPRESSING HOST COSTIMULATION MOLECULES |
摘要 |
An antiviral vaccine that encodes costimulation molecules for increasing immune response to the particular virus at issue is provided herein. In an illustrative embodiment, in mice lacking both B7-1 and B7-2 (B7KO), the increased severity of HSV infection has confirmed the importance of these molecules in generation of HSV-specific immunity. To test the concept that B7-1 or B7-2 expression by replication-defective HSV could augment its immunogenicity and protective capacity, the present inventors constructed replication-defective HSV-2 encoding B7-1 or B7-2. Both viruses partially reconstituted immune responses to HSV compared with replication-defective virus alone when used to immunize B7KO mice, indicating that the increased responsiveness to virus could be attributed to virus-encoded B7 molecules.
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申请公布号 |
US2010098726(A1) |
申请公布日期 |
2010.04.22 |
申请号 |
US20090497597 |
申请日期 |
2009.07.03 |
申请人 |
MORRISON LYNDA A;THEBEAU LYDIA G;SCHRIMPF JANE E |
发明人 |
MORRISON LYNDA A.;THEBEAU LYDIA G.;SCHRIMPF JANE E. |
分类号 |
A61K39/12;A61K35/76;A61K39/245 |
主分类号 |
A61K39/12 |
代理机构 |
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