<p>Provided herein are immunogenic compositions comprising fusion proteins, the fusion proteins comprising lentivirus gp41 or a fragment thereof, a trimerization or oligomerization motif and an immunoenhancer that elicit potent and broad HIV neutralizing antibody responses in the immunized hosts. Also disclosed are methods of making and using the immunogenic compositions.</p>
申请公布号
WO2010045613(A1)
申请公布日期
2010.04.22
申请号
WO2009US61088
申请日期
2009.10.16
申请人
NEW YORK BLOOD CENTER;JIANG, SHIBO;QI, ZHI;PAN, CHUNGEN