GEMININ INHIBITORS AS TUMOR TREATMENT

摘要

Disclosed herein are methods of selectively killing cancer cells. The methods include contacting a cancer cell with a compound that inhibits geminin. Disclosed herein are methods that selectively induce apoptosis in cancer cells in the absence of a cell cycle checkpoint inhibitor. Also disclosed are methods for identifying a compound that selectively kills cancer cells, including contacting a cancer cell with a test compound, determining the cell cycle status of the cancer cell, and determining geminin activity in the cancer cell, wherein a compound that induces DNA re-replication, cell cycle arrest, or apoptosis and inhibits geminin activity is a compound that selectively induces apoptosis of cancer cells.