发明名称 |
PREPARATION METHOD OF BIODEGRADABLE MICRO-PARTICLES CONTAINING DRUGS |
摘要 |
The disclosure provides a method to form sustained release drug-containing microparticles with a biodegradable polymer. The method involves forming a polymer- drug-organic solvent phase, and dispersing the polymer-drug-organic solvent phase in an aqueous suspension of an inorganic gel, which may be hydroxyapatite. The hydroxyapatite appears to coat the polymer-drug-solvent droplets to prevent them coalescing. The solvent then evaporates with stirring of the dispersion, at which time the droplets solidify to drug-containing microparticles. The inorganic gel allows suitably small microparticles to form without use of an organic emulsifier. |
申请公布号 |
WO2010014176(A3) |
申请公布日期 |
2010.04.22 |
申请号 |
WO2009US04273 |
申请日期 |
2009.07.23 |
申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS;KIM, CHERNG-JU |
发明人 |
KIM, CHERNG-JU |
分类号 |
A61K9/16;A61K38/09;A61K47/24;A61K47/34;A61P35/00 |
主分类号 |
A61K9/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|