N1-2-THIOPHENE-2-YLETHYL-N2-SUBSTITUTED BIGUANIDE DERIVATE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS ACTIVE INGREDIENTS

摘要

The present invention relates to an N1-2-thiophene-2-ylethyl-N2-substituted  biguanide derivate expressed in Chemical Formula 1, a pharmaceutically allowable salt thereof, a preparation method thereof, and a pharmaceutical composition containing the same as active ingredients. The N1-2-thiophene-2-ylethyl-N2-substituted  biguanide derivate of the present invention shows a superior hypoglycemic action and a superior hypolipidemic action even at a low dosage as compared with conventional drugs, and thus can be used for prevention and treatment of diabetes, non-insulin-dependent diabetes, obesity, the metabolic syndrome and arteriosclerosis, or cancer involving P53 gene deficiency.