ALPHA-HELIX MIMETIC WITH FUNCTIONALIZED PYRIDAZINE
摘要
The synthesis of new a-helix scaffolds mimicking i, i+3 or i+4, i+7 residues, was accomplished. The common pyridazine heterocycle originates from the easily available dimethyl pyridazine-3,6-dicarboxylate building block. These scaffolds may be thought of as synthetic counterparts of amphiphilic a-helices having a hydrophilic face along one side and a hydrophobic face along the other side of the helix.
申请公布号
WO2010011864(A3)
申请公布日期
2010.04.22
申请号
WO2009US51585
申请日期
2009.07.23
申请人
THE SCRIPPS RESEARCH INSTITUTE;REBEK, JULIUS, JR.;MOISAN, LIONEL;CARELLA, ALEXANDRE;MANN, ENRIQUE