发明名称 |
PROCESS FOR MAKING MONTELUKAST AND INTERMEDIATES THEREFOR |
摘要 |
The reaction of methylmagnesium halide is improved by the presence of a cerium (III) salt such as cerium trichloride. The reactions are typically associated with the production of montelukast, a pharmaceutically useful compound of the following formula and salts thereof. Further enhancements can be derived from certain intermediates, salts thereof and/or purification thereof before and/or after the reaction involving methylmagnesium halide.
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申请公布号 |
US2010099879(A1) |
申请公布日期 |
2010.04.22 |
申请号 |
US20090576773 |
申请日期 |
2009.10.09 |
申请人 |
BENOVSKY PETR;THIJS LAMBERTUS;OVEREEM ARJANNE;CASTULIK JAKUB;ZHU JIE;BARTOS PETR;SKOUMAL RADOMIR |
发明人 |
BENOVSKY PETR;THIJS LAMBERTUS;OVEREEM ARJANNE;CASTULIK JAKUB;ZHU JIE;BARTOS PETR;SKOUMAL RADOMIR |
分类号 |
C07D215/18 |
主分类号 |
C07D215/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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