发明名称 |
PHARMACEUTICAL FORMULATION 514 |
摘要 |
The present invention relates to a pharmaceutical formulation comprising the drug 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one in a solid dispersion with a matrix polymer that exhibits low hygroscopicity and high softening temperature, such as copovidone. The invention also relates to a daily pharmaceutical dose of the drug provided by such a formulation. In addition, the invention relates to the use of a matrix polymer that exhibits low hygroscopicity and high softening temperature in solid dispersion with 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one for increasing the bioavailability of the drug. |
申请公布号 |
US2010098763(A1) |
申请公布日期 |
2010.04.22 |
申请号 |
US20090574801 |
申请日期 |
2009.10.07 |
申请人 |
ASTRAZENECA AB;ABBOT GMBH & CO. KG |
发明人 |
BECHTOLD MICHAEL KARL;PACKHAEUSER CLAUDIA BETTINA;FASTNACHT KATJA MAREN;LIEPOLD BERND HARALD;STEITZ BENEDIKT;CAHILL JULIE KAY;LENNON KIERAN JAMES |
分类号 |
A61K9/14;A61K31/502;A61P35/00 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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