| 摘要 |
The invention relates to a compound of general formula (I) wherein Ar/Arare independently from each other phenyl or pyridinyl, which are optionally substituted by one or two substituents, selected from the group consisting of halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, lower alkyl substituted by alkoxy, lower alkyl substituted by cyano, lower di-alkyl amino, pyridinyl or cyano; Ris hydrogen, lower alkyl,-(CH)O-lower alkyl, or cycloalkyl: Ris-S(O)-lower alkyl or-C(O)-lower alkyl; or Rand Rform together with the N-atom to which they are attached a pyrrolidin-2-one or a piperidin-2-one group; Ris hydrogen, halogen or lower alkyl; Ris hydrogen or lower alkyl; R/Rare independently from each other hydrogen, lower alkyl, lower alkyl substituted by halogen, lower alkyl substituted by hydroxy or cycloalkyl; or Rand Rform together with the carbon-atom to which they are attached a cycloalkyl group; or to a pharmaceutically active salt thereof. It has been found that the present compounds are high potential NK-3 receptor antagonists for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).
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