发明名称 Aptamer constructs
摘要 Provided are RNA oligonucleotides having an aptamer flanked by two self-cleaving ribozymes. Vectors encoding the oligonucleotides, and cells transfected with these vectors are also provided. Additionally, methods of inhibiting replication of a virus in a cell, methods of treating an organism with an aptamer, methods of determining whether a test aptamer is effective in inhibiting the function of a target of the aptamer in a cell, and methods of expressing an RNA aptamer in a cell are provided.
申请公布号 US7700759(B2) 申请公布日期 2010.04.20
申请号 US20040999686 申请日期 2004.11.30
申请人 ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY 发明人 PRASAD VINAYAKA R.;JOSHI PHEROZE
分类号 C07H21/04;C07H21/02;C07K14/16;C12N15/113;C12N15/115;C12N15/867;C12Q1/70 主分类号 C07H21/04
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