发明名称 |
Polypeptide for unstabilizing protein in cells under aerobic conditions and DNA encoding the same |
摘要 |
To identify a domain in HIF-1α protein, which participates in stabilization of a fused protein, DNA encoding the following polypeptide (A) or (B) is provided: (A) a polypeptide having the amino acid sequence of SEQ ID NO: 1 (B) a polypeptide having an amino acid sequence comprising at least 16 amino acid residues in the amino acid sequence of SEQ ID NO: 1, and imparting stability dependent on an oxygen concentration to other protein in a cell harboring a fused protein, when the polypeptide is fused with a nuclear localization signal and the other protein to form the fused protein.
|
申请公布号 |
US7700754(B1) |
申请公布日期 |
2010.04.20 |
申请号 |
US20020479700 |
申请日期 |
2002.06.04 |
申请人 |
HIRAOKA MASAHIRO;KONDOH SHINAE;HARADA HIROSHI |
发明人 |
HIRAOKA MASAHIRO;KONDOH SHINAE;HARADA HIROSHI |
分类号 |
C07H21/04;C07H21/02;C07K14/00;C07K14/47 |
主分类号 |
C07H21/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|