发明名称 REGULATORY SYSTEM FOR INDUCIBLE EXPRESSION OF GENES WITH LAMBDOID PROMOTERS
摘要 The invention relates to a regulation system for inducible expression of genes, comprising a lambdoid promoter, a gene coding for a repressor for the lambdoid promotor and a gene coding for an antirepressor of the repressor, which antirepressor is under the influence of an inducible promotor. The invention further relates to a regulatory replicon, comprising said gene coding for an antirepressor, an expression system, comprising said regulatory replicon, and an expression vector based on a lambdoid promotor, and also to a method for producing a gene product in a heterologous host, by providing a culture of a host comprising a heterologous sequence which codes for the gene product, wherein the expression of the heterologous sequence is under the control of a regulation system, a gene coding for a repressor for the lambdoid promotor and a gene coding for an antirepressor, and by inducing the promotor of the antirepressor gene.
申请公布号 CA2287541(C) 申请公布日期 2010.04.20
申请号 CA19982287541 申请日期 1998.04.23
申请人 VLAAMS INTERUNIVERSITAIR INSTITUUT VOOR BIOTECHNOLOGIE 发明人 MERTENS, NICO MAURICE AUGUST CORNEEL;REMAUT, ERIK RENE;FIERS, WALTER CHARLES
分类号 C12N15/09;C12N15/73;A61K38/00;A61K45/00;A61K48/00;A61P43/00;C07K14/01;C07K14/52;C12N1/21;C12N9/02;C12N15/63;C12P21/02 主分类号 C12N15/09
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