发明名称 |
Recombinant vector containing infectious human cytomegalovirus genome with preserved wild-type characteristics of clinical isolates |
摘要 |
A recombinant vector containing infectious genome of human cytomegalovirus (HCMV) and being useful for the production of reconstituted HCMV virus retaining phenotypic characteristics of a clinical virus isolate including the ability to grow on endothelial cells and to induce microfusion is characterized in that it is obtainable by inserting DNA from a clinical isolate of HCMV virus into a bacterial cloning vehicle. Such vector can be used e.g., for production of reconstituted HCMV virus retaining the phenotypic characteristics of a parental clinical isolate and for studying genes and functions of genes of HCMV virus. A further aspect are mutant viruses and inter alia their use for studying aspects of infectivity of HCMV virus.
|
申请公布号 |
US7700350(B2) |
申请公布日期 |
2010.04.20 |
申请号 |
US20050180000 |
申请日期 |
2005.07.13 |
申请人 |
VICAL INCORPORATED |
发明人 |
HAHN GABRIELE |
分类号 |
C12N15/00;A61K39/245;A61K48/00;C12N1/21;C12N7/00;C12N7/01;C12N7/04;C12N15/33;C12N15/869 |
主分类号 |
C12N15/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|