发明名称 |
Gene associated with leishmania parasite virulence |
摘要 |
The invention relates to the field of combating leishmaniases. Said invention results from the isolation, from wild isolates of Leishmania major, of a protein-coding gene known as LmPDI which has two regions that are identical to the sequence (Cys-Gly-His-Cys) of the potential active site of the protein disulphide isomerases (PDI). The LmPDI protein is predominantly expressed in the most virulent isolates of the parasite. Said protein forms a novel therapeutic target for developing anti-leishmaniasis medicaments and a novel element that can be used in the composition of immunogenic, and possibly vaccinating, preparations which are intended to protect a human or animal host against Leishmania.
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申请公布号 |
US7700121(B2) |
申请公布日期 |
2010.04.20 |
申请号 |
US20030733232 |
申请日期 |
2003.12.12 |
申请人 |
INSTITUT PASTEUR;INSTITUT PASTEUR DE TUNIS |
发明人 |
BEN ACHOUR YOSSER;CHENIK MEHDI;LOUZIR HECHMI;DELLAGI KOUSSAY |
分类号 |
A61K39/00;A61K39/002;A61K39/02;A61K39/39;A61K45/00;C07H21/04;C12N9/90 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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